Protein name:
Serine/arginine-rich splicing factor 1 ;
Alternative:
Splicing factor, arginine/serine-rich 1 ;
Organism:
Pig (Sus scrofa).
General Annotation
Sub Unit:
Consists of two polypeptides of p32 and p33. In vitro, self-associates and binds SRSF2, SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with SAFB/SAFB1. Interacts with PSIP1/LEDGF. Interacts with SRPK1. Identified in the spliceosome C complex. Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus).
Function:
Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing.
Subcellular Location:
Cytoplasm
Nucleus
Nucleus speckle
Shuttles between the nucleus and the cytoplasm.
Protein Attributes:
50:
MSGGGVIRGP | AGNNDCRIYV | GNLPPDIRTK | DIEDVFYKYG | AIRDIDLKNR |
100:
RGGPPFAFVE | FEDPRDAEDA | VYGRDGYDYD | GYRLRVEFPR | SGRGTGRGGG |
150:
GGGGGGAPRG | RYGPPSRRSE | NRVVVSGLPP | SGSWQDLKDH | MREAGDVCYA |
200:
DVYRDGTGVV | EFVRKEDMTY | AVRKLDNTKF | RSHEGETAYI | RVKVDGPRSP |
248:
SYGRSRSRSR | SRSRSRSRSN | SRSRSYSPRR | SRGSPRYSPR | HSRSRSRT
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
Pig
Bovine
ELISA Kit for Pig Serine/arginine-rich splicing factor 1
ELISA Kit for Pig Serine/arginine-rich splicing factor 1
ELISA Kit for Pig Serine/arginine-rich splicing factor 1
ELISA Kit for Pig Serine/arginine-rich splicing factor 1
ELISA Kit for Pig Serine/arginine-rich splicing factor 1
CLIA Kit for Pig Serine/arginine-rich splicing factor 1
CLIA Kit for Pig Serine/arginine-rich splicing factor 1
CLIA Kit for Pig Serine/arginine-rich splicing factor 1
CLIA Kit for Pig Serine/arginine-rich splicing factor 1
CLIA Kit for Pig Serine/arginine-rich splicing factor 1
Polyclonal Antibody for Pig Serine/arginine-rich splicing factor 1
Polyclonal Antibody for Pig Serine/arginine-rich splicing factor 1
Polyclonal Antibody for Pig Serine/arginine-rich splicing factor 1
Polyclonal Antibody for Pig Serine/arginine-rich splicing factor 1
Polyclonal Antibody for Pig Serine/arginine-rich splicing factor 1
Monoclonal Antibody for Pig Serine/arginine-rich splicing factor 1
Monoclonal Antibody for Pig Serine/arginine-rich splicing factor 1
Monoclonal Antibody for Pig Serine/arginine-rich splicing factor 1
Monoclonal Antibody for Pig Serine/arginine-rich splicing factor 1
Monoclonal Antibody for Pig Serine/arginine-rich splicing factor 1
Protein for Pig Serine/arginine-rich splicing factor 1
Protein for Pig Serine/arginine-rich splicing factor 1
Protein for Pig Serine/arginine-rich splicing factor 1
Protein for Pig Serine/arginine-rich splicing factor 1
Protein for Pig Serine/arginine-rich splicing factor 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue :
Fetal skeletal muscle .